A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis.

Bohnacker S, Henkel FDR, Hartung F, Geerlof A, Riemer S, Prodjinotho UF, Salah EB, Mourão ASD, Bohn S, Teder T, Thomas D, Gurke R, Boeckel C, Ud-Dean M, König AC, Quaranta A, Alessandrini F, Lechner A, Spitzlberger B, Kabat AM, Pearce E, Haeggström JZ, Hauck SM, Wheelock CE, Jakobsson PJ, Sattler M, Voehringer D, Feige MJ, da Costa CP, Esser-von Bieren J.
Sci Immunol. 2024 Dec 6;9(102):eadl1467. doi: 10.1126/sciimmunol.adl1467.
 

Extracellular vesicle miRNAs drive aberrant macrophage responses in NSAID-exacerbated respiratory disease.

Hartung F, Haimerl P, Schindela S, Mussack V, Kirchner B, Henkel FDR, Bernhardt U, Zissler UM, Santarella-Mellwig R, Pfaffl M, Schmidt-Weber CB, Chaker AM, Esser-von Bieren J.
Allergy. 2024 Jul;79(7):1893-1907. doi: 10.1111/all.16117.
 

Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.

Hildenbrand K*, Bohnacker S*, Menon PR, Kerle A, Prodjinotho UF, Hartung F, Strasser PC, Catici DAM, Rührnößl F, Haslbeck M, Schumann K, Müller SI, da Costa CP, Esser-von Bieren J, Feige MJ.
Sci Adv. 2023 Oct 27;9(43):eadg6874. doi: 10.1126/sciadv.adg6874. * equal contribution
 

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma.
Lechner A, Henkel FDR, Hartung F, Bohnacker S, Angioni C., Schreiber Y., Alessandrini F., Haimerl P., Ge Y., Thomas D., Kabat A., Pearce E.J., Ohnmacht C., Murray P.J., Chaker A.M., Schmidt-Weber C.B., Esser-von Bieren J.
J Allergy Clin Immunol. 2022, S0091-6749(21)02741-X
 

Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages. Bohnacker S, Hartung F, Henkel, FDR, Quaranta A, Kolmert J, Priller A, Ud-Dean M, Giglberger J, Kugler LM, Pechtold L, Yazici S, Lechner A, Erber J, Protzer U, Lingor P, Knolle P, Chaker AM, Schmidt-Weber CB, Wheelock CE, Esser-von Bieren J.
Mucosal Immunol. 2022 15(3):515-524.
 

Inflammatory macrophage memory in NSAID-exacerbated respiratory disease.
Haimerl P, Bernhard U, Schindela S, Henkel FDR, Lechner A, Zissler UM, Pastor X, Thomas D, Cécil A, Ge Y, Haid M, Prehn C, Tokarz J, Heinig M, Adamski J, Schmidt-Weber CB, Chaker AM, Esser-von Bieren J.
J Allergy Clin Immunol. 2021, 147(2):587-599.
 

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.
de Los Reyes Jiménez M, Lechner A, Alessandrini F, Schindela S, Trompette A, Haimerl P,  Thomas D, Haslbeck M, Henkel FDR, Prazeres da Costa C, Feige MJ, Chaker AM, Dehne N, Brüne B, Nüsing R, Nockher WA, Ohnmacht C, Marsland BJ, Harris NL, Schmidt-Weber CB, Esser-von Bieren J.
Science Translational Medicine 2020, 12(540)
 

House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions.
Henkel FDR, Friedl A, Haid M, Thomas D, Bouchery T, Haimerl P, de Los Reyes Jiménez M, Alessandrini F, Schmidt-Weber CB, Harris NL, Adamski J, Esser-von Bieren J.
Allergy 2019, 74(6):1090-1101.
 

Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways.
Dietz K, de los Reyes Jiménez M, Gollwitzer ES, Chaker A, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J. ,
J Allergy Clin Immunol. 2017 139(4):1343-1354.e6.


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